英:[daɪ'sʌlfəræm]
美:[daɪ'sʌlfəˌræm]
英:[daɪ'sʌlfəræm]
美:[daɪ'sʌlfəˌræm]
〔USP〕双硫仑,戒酒硫:一种抗氧化剂,C10-H20N2S4,为白色至灰白色结晶粉末,抑制酒精代谢产生的乙醛的氧化,结果体内乙醛浓度升高。故口服戒酒硫后再饮酒,可出现极不舒适的症状(见mal rouge),对此产生对酒精厌恶感,以治疗慢性酒精中毒
disulfide + thiourea + amyl
The first known use of disulfiram was in 1946
disulfiramnoun
a compound C10H20N2S4 that causes a severe physiological reaction to alcohol and is used especially in the treatment of alcoholism called alsotetraethylthiuram disulfide see antabuse
1 Conclusion Qingkailing injection has a significant effect on shortening the course of disulfiram-like reaction, which can be promoted for clinical application.
结论清开灵注射液可显著缩短双硫仑样反应的病程,并且无不良反应,可临床推广应用。
2 The dosage of disulfiram we used provided more of a tickle than a kick to the virus, but this could be enough.
3 The time of symptom soothing of disulfiram-like reaction were noted.
观察两组患者用药后双硫仑样反应症状缓解的时间。
4 Although some approved cancer drugs and others in development interfere with the same protein cleanup process, known as the ubiquitin-proteasome system, disulfiram targets only a specific molecular complex within this machinery.
5 "This trial clearly demonstrates that disulfiram is not toxic and is safe to use, and could quite possibly be the game changer we need," she said in a statement.
6 Medication - Antabuse, or disulfiram, a tablet which makes the taker sick if he or she drinks alcohol.
7 But they were more effective than a much older and more widely known medication for alcoholism called Antabuse, or disulfiram.
8 The same principle underlies the use of the medication disulfiram as a treatment for alcohol abuse.
9 At the moment, Columbia University Medical School in New York is recruiting patients for the first clinical trial of disulfiram for PTLDS.
10 Side effects of metronidazole include a metallic taste, nausea, a disulfiram-like effect with alcohol, interaction with warfarin, and peripheral neuropathy.
甲硝唑的副作用包括口腔金属味、恶心、饮酒后有戒酒硫样感、与华法林相互作用以及周围神经系统疾病。
11 In his clinical practice, he’d occasionally prescribed Antabuse (disulfiram) to patients who struggled with alcohol addiction.
12 Around this time, manufacturers began using a chemical known as disulfiram to accelerate the vulcanization of rubber.
13 The researchers also confirmed that disulfiram slows the growth of breast cancer tumors in mice, particularly if combined with a copper supplement, which was already known to enhance its effects.
14 Our nationwide epidemiological study reveals that patients who continuously used disulfiram have a lower risk of death from cancer compared to those who stopped using the drug at their diagnosis.
15 They then showed that when the mice broke down disulfiram, its main metabolite, ditiocarb, forms a complex with copper that blocks the machinery that cells use to dispose of misfolded and unneeded proteins.
16 Method:460 clinicians were investigated with self-designed questionnaire to acquire clinicians knowledge about "disulfiram-like reaction".
方法:460例临床医生使用自行设计的问卷进行“戒酒硫样反应”知识认知情况调查。
17 Where disulfiram punishes with a bang, tiparamate saps pleasure with a whimper.
18 Hangovers and the anti-alcohol drug disulfiram produce pretty much the same effect.
19 The medication disulfiram prescribed to alcoholics to prevent them from drinking causes these same symptoms.
20 Starting in the 1970s, scientists found that disulfiram killed cancer cells and slowed tumor growth in animals.
1 化学分子式
DDT EDTA GHB BZP salt alcohol formula cholesterol glucose caffeine cocaine heroin nicotine propane ammonia methane serotonin ether dopamine silica alum octane LSD morphine TNT methamphetamine ibuprofen methanol acetone urethane amphetamine choline formaldehyde creatinine urea glutamine warfarin menthol histamine codeine benzene ethylene butane borax retinol paracetamol tryptophan sucrose tyrosine taurine leucine phenol glucosamine styrene glyphosate glycerol capsaicin propylene dioxin ketamine homocysteine arginine xylitol lysine quercetin chloroform methotrexate alumina glycine zirconia camphor diazepam acetylene cysteine melamine ephedrine metronidazole catechin cisplatin naproxen alanine toluene methionine quinine isoflavone ethane bupropion thyroxine purine phenylalanine inositol allicin hexane saccharin acetaldehyde hydroquinone acrylamide atropine fluorescein magnesia betaine serine propranolol aniline colchicine adenine proline sorbitol diphenhydramine chlorhexidine Pyridoxine theobromine noradrenaline vanillin histidine coumarin hydrazine cytosine tetrahydrocannabinol naphthalene guanine mescaline valine isoniazid mannitol indomethacin thymine pyrimidine isopropanol threonine tyramine phenolphthalein alizarin butadiene heptachlor zidovudine phosgene allantoin trichloroethylene nitrofurantoin isoprene cetane benzocaine ornithine uracil nitroglycerine benzaldehyde pyridine acetonitrile cyanogen pentane cystine imipramine carbaryl asparagine butanol halothane nitromethane pyrrole heptane rotenone chloral isobutane imidazole phosphine creatine Aldrin chlordane acrylonitrile ethylbenzene nitrobenzene perchloroethylene dopa dieldrin thymol indole phthalocyanine tris benzoin quinoline iodoform pentazocine lithia Amytal nicotinamide hyoscine isoleucine catechol cyclohexane acridine phenothiazine propanol ethylenediamine paraldehyde hyoscyamine apomorphine cresol levamisole lignocaine temazepam phorbol deoxyribose alloxan piperazine sulphanilamide resorcinol tolbutamide diazomethane trichloroethane terbutaline pyrrolidone pyrene eugenol silane benzopyrene sphingosine menadione naphthol cyclopropane ethambutol ninhydrin spermine anthracene psoralen hypoxanthine physostigmine stilbene dehydrocholesterol spermidine acetamide santonin litharge papaverine pyrogallol baryta dioxane thiourea furfural haematoxylin frusemide piperidine thiomersal dapsone dichlorvos zineb maneb tetrahydrofuran isooctane iproniazid guanidine dimercaprol tryptamine pirimicarb metaldehyde timolol geraniol furan gossypol caprolactam cementite enflurane chloroprene tacrine squalene pinene cyanamide anthraquinone acesulfame benzoquinone hypericin flavone cannabinol phenanthrene phenylenediamine aldol pyrrolidine muscimol cinchonine ribitol diphenylamine thiazole fuchsin trichlorophenol rosaniline dithizone diborane tropolone cumene triazole barbitone citral decane tetrafluoroethylene thiram azobenzene dihydroxyacetone diquat xanthene muscarine octopamine coniine geranial isobutylene guaiacol acetanilide galactosamine morpholine thoria erythritol biguanide cacodyl purpurin coumarone isatin indene indican orcinol sarcosine creosol tetrazole ketene nonane indigotin strontia phenylthiocarbamide carbazole oxazole salicylic acid nitrogen dioxide cream of tartar white arsenic ascorbic acid quinic acid tartar emetic ammonium carbonate chloric acid hippuric acid glucuronic acid arachidonic acid neuraminic acid nicotinic acid usnic acid uric acid pyruvic acid nalidixic acid ethacrynic acid maleic acid ellagic acid tartaric acid phthalic anhydride caprylic acid picric acid adipic acid isethionic acid phosphoric acid toluidine blue pyrophosphoric acid gallic acid citric acid methacrylic acid caproic acid fumaric acid metaphosphoric acid microcosmic salt ethylene oxide propionic acid valproic acid malonic acid myristic acid lysergic acid
2 又名
salt alcohol heroin aspirin serotonin ether dopamine silica TNT ibuprofen acetone urethane amphetamine formaldehyde ethylene paracetamol glyphosate propylene dioxin chloroform methotrexate alumina acetylene alanine toluene inositol saccharin acetaldehyde hydroquinone xylene adenine vanillin guanine mescaline thymine alizarin phosgene cetane benzocaine nitroglycerine acetonitrile carbaryl chloral thymol tris benzoin iodoform Amytal catechol pentobarbitone sulphanilamide resorcinol tolbutamide trichloroethane eugenol menadione hypoxanthine stilbene acetamide pyrogallol dapsone zineb maneb cyanamide aldol arsine cumene barbitone guaiacol indican orcinol sarcosine creosol